Neurology® Podcast

In the first segment, Dr. James Grogan talks with Dr. David Llewellyn about his Neurology: Clinical Practice paper on predictors of dementia misclassification when using brief cognitive assessments. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Dr. Rob M.A. de Bie on a randomized delayed-start trial of Levodopa in Parkinson’s Disease, published in the New England Journal of Medicine. The article can be found here: https://www.nejm.org/doi/full/10.1056/NEJMoa1809983.

1. A multicentre comparison of MOG-IgG cell based assays. 2. [What’s Trending]: the DEFUSE 3 study. In the first segment, Dr. Stacey Clardy talks with Dr. Paddy Waters about his paper on a multicentre comparison of MOG-IgG cell based assays. In the second part of the podcast, Dr. Andrew Southerland focuses his interview with Dr. Adam de Havenon on the DEFUSE 3 study.  CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. The prevalence of MS in the United States: A population-based estimate using health claims data. 2. [What’s Trending]: Neurology on the Hill and advocacy issue. In the first segment, Dr. Stacey Clardy talks with Dr. Mitch Wallin about his paper examining a population-based estimate on the prevalence of MS in the United States. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Dr. Nick Johnson on Neurology on the Hill and advocacy issues. CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by answering the multiple-choice questions in the online Podcast quiz.

1. Quality Improvement in Neurology: Universal Neurology Quality Measurement Set Executive Summary2. [What’s Trending]: The 2018 report of the Lancet Countdown on health and climate change: shaping the health of nations for centuries to come. In the first segment, Dr. Stacey Clardy talks with Dr. Wayne Anderson and Dr. Justin Martello about their paper on quality improvement in neurology. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Dr. Nick Watts on health and climate change shaping the health of nations for centuries to come. DISCLOSURES: Dr. Stacey Clardy has received research support from Western Institute for Biomedical Research (WIBR). Dr. Wayne Anderson reports no disclosures. Dr. Justin Martello has received travel funding or speaker honoraria from 1) Teva, cash, (2) Abbvie, cash, (3) Lundbeck, cash and is a member of the AAN’s Quality and Safety Subcommittee. CME Opportunity: Listen to this week’s Neurology Podcast and earn 0.5 AMA PRA Category 1 CME Credits™ by ans

1.Physical activity, common brain pathologies, and cognition in community-dwelling older adults 2. [What’s Trending]: Deep space medicine. In the first segment, Dr. Jeff Burns talks with Dr. Aron Buchman about his paper on physical activity, common brain pathologies, and cognition in community-dwelling older adults. In the second part of the podcast, Dr. Jason Crowell focuses his interview with Dr. Alejandro Rabinstein on the medicine of deep space. Dr. Jeff Burns has served on the DSMB for three NIH-funded trials; has received honorarium and travel for speaking at an Astra-Zeneca symposium; has served on the editorial board of Journal of Alzheimer's Disease; has served as a consultant for protocol development for Stage 2 Innovations; has received commercial research support from Lilly, Avid Radiopharmaceuticals, Toyama Chemical Company, Merck, Biogen, AbbVie, vTv Therapeutics, Janssen, and Roche and for investigator-initiated studies from Eli Lilly and Astra-Zeneca; has received governmental research support

1.Quality of Life Outcomes in Patients Presenting for Evaluation of Central Nervous System Tumors 2. [What’s Trending]: 'Landmark study’ shows brain cells revamp their DNA, perhaps sparking Alzheimer’s disease. In the first segment, Dr. Ted Burns talks with Dr. Irene Katzan about her paper on quality of life outcomes in patients presenting for evaluation of central nervous system tumors. In the second part of the podcast, Dr. Jeff Burns focuses his interview with Dr. Jerold Chun on a 'Landmark study’ showing brain cells revamp their DNA, perhaps sparking Alzheimer’s disease.Dr. Ted Burns has served on scientific advisory boards for Argenx, Momenta, received travel funding or speaker honoraria from Argenx, Alexion and received support for consulting activities from UCB Pharma, CSL Behring, Momenta, Argenx. Dr. Irene Katzan has served on editorial boards for Stroke (American Stroke Association), 2014-present Editorial Board - Circulation: Cardiovascular Quality & Outcomes (American Heart Association) 2013 –

1. Reducing neurodisparity: Recommendations of the 2017 AAN Diversity Leadership Program 2. [What’s Trending]: Mapping Symptoms to Brain Networks with the Human Connectome. In the first segment, Dr. Teshamae Monteith talks with Dr. Roy Hamilton about his paper on reducing neurodisparity. In the second part of the podcast, Dr. Stacey Clardy focuses her interview with Dr. Michael D. Fox on mapping symptoms to brain networks with the human connectome.DISCLOSURES Dr. Teshamae Monteith has served on Scientific Advisory Boards for Lilly, Supernus, Teva, Electrocore, Promius and is an editorial advisory board member for Neurology. Dr. Roy Hamilton has served without compensation on the scientific advisory board for an NIH-funded R21 project titled ""Combining tDCS and neurorehabilitation to treat age-related deficits of mobility and cognition (UPfront Walking Study) as the data safety monitor. Dr. Hamilton has served on editorial boards for (1)Cognitive and Behavioral Neurology, editorial board member, and (2)Restor

1. Brain death, the determination of brain death, and member guidance for brain death accommodation requests: AAN position statement. 2. [What’s Trending]: On tau protein and Alzheimer dementia symptoms. In the first segment, Dr. Jason Crowell talks with Dr. James Russell about his paper on brain death, the determination of brain death, and member guidance for brain death accommodation requests. In the second part of the podcast, Dr. Jeff Burns focuses his interview with Dr. Matthew Brier on tau protein and Alzheimer dementia symptoms.DISCLOSURES: Dr. Jason Crowell reports no disclosures. Dr. James Russell has served on Scientific Advisory Boards for Cytokinetics - Data Monitoring Board PROTOCOL CY 5022 A PHASE 2, MULTI-CENTER, DOUBLE-BLIND, RANDOMIZED, DOSE- RANGING, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY, SAFETY, AND TOLERABILITY OF CK-2127107 IN PATIENTS WITH AMYOTROPHIC LATERAL SCLEROSIS (ALS). Dr. James Russell received travel funding from 1) Non-profit - Mexican Academy of Neurology - Funded

1. Aspirin Reduces Long Term Stroke Risk in Women with Prior Hypertensive Disorders of Pregnancy 2. [What’s Trending]: Top-selling drug price hikes and patients bearing the cost. In the first segment, Dr. Andrew Southerland talks with Dr. Eliza Miller about her paper on aspirin reducing the long term stroke risk in women with prior hypertensive disorders of pregnancy. In the second part of the podcast, Dr. Ted Burns focuses his talk with Casey Ross on makers of top-selling drugs hiking prices and patients bearing the costs.DISCLOSURES: Dr. Eliza Miller has served on Editorial Boards for Stroke, Assistant Editor, InterSECT, 2017-2018. Dr. Eliza Miller Research Support, Government Entities including (1) NIH NINDS 5U10NS086728-05, Fellow, 2017-2018 (2) NIH NINDS U01 NS095869, Subsite PI, 2018 (3) NIH NCATS 5KL2TR001874-02, KL2 Scholar, 2018-2020 and she has received research support from Foundations and Societies including American Medical Association Foundation and Louis V. Gerstner Foundation. Casey Ross repor

1. Development and validation of a score to detect paroxysmal atrial fibrillation after stroke. 2. [What's Trending]: Drug pricing and the Institute for Clinical and Economic Review framework. In the first segment, Dr. Andy Southerland talks with Dr. Timo Uphaus about his paper on the development and validation of a score to detect paroxysmal atrial fibrillation after stroke. In the second part of the podcast, Dr. Gordon Smith focuses his interview with Dr. Steve Pearson on the Institute for Clinical and Economic Review and drug pricing. DISCLOSURES: Dr. Southerland has severed on editorial boards for the Journal Neurology and is Section Editor for the Neurology Podcast. Dr. Timo Uphaus reports no disclosures. Dr. A. Gordon Smith has served on the scientific advisory board of the Regenesis Data Monitoring Committee; has served on the editorial boards for Continuum and Annals of Clinical and Translational Neurology; has served as a consultant for Regenesis; has served on the speakers' bureau for Alexion; has r

1. Continuous EEG is Associated with Favorable Hospitalization Outcomes for Critically Ill Patients. 2. [What's Trending]: Investigation of "generic" cartel. In the first segment, Dr. Andy Schomer talks with Dr. Chloe Hill on the association between continuous EEG and favorable hospitalization outcomes for critically ill patients. In the second part of the podcast, Dr. Ted Burns focuses his interview with Christopher Rowland of the Washington Post on the investigation into a generic drug "cartel." Dr. Chloe Hill has served as an epileptologist for clinical procedures or imaging studies; and has received governmental research support from the National Institutes of Health/National Institute of Neurological Disorders and Stroke. Dr. Ted Burns has served on the scientific advisory boards for Argenx and Momenta; has received funding for travel or speaker honoraria from Argenx and Alexion; has served on editorial boards as the Section Editor for Neurology Podcast and as Section Deputy Editor, Neurology Podcast; an

1. The ethical and philosophical implications of gene editing. 2. [What’s Trending]: Scientific and societal impact gene editing , Dr. Jason Crowell talks with Dr. Josephine Johnston of the Hastings Center on the ethical and philosophical implications of gene editing. In the second part of the podcast, Dr. Stacey Clardy focuses her interview with Dr. Stefan Pulst on the scientific and societal impact of the recent first reported gene editing using the CRISPR technology. Dr. Jason Crowell reports no disclosures. Dr. Josephine M. Johnston has received honoraria for speaking or travel from The Hastings Center, the University of Toronto, Danbury Hospital, World Science festival, the Yale School of Medicine, the University of Pennsylvania Law School, the Royal Society of New Zealand, McGill University, Dalhousie University, and Queensland University of Technology; and has received foundation/society research support from the John Templeton Foundation. Dr. Clardy serves as the Podcast Section Editor for Neurology a

1. Body mass index, but not vitamin D status, is associated with brain volume change in MS. 2. [What’s Trending]: preventing firearm injury. In the first segment, Dr. Stacey Clardy talks with Dr. Ellen Mowry about her paper on the associations between body mass index and brain volume change in MS. In the second part of the podcast, Dr. Ted Burns focuses his interview with Dr. Christine Laine on preventing firearm injury. Dr. Clardy serves as the Podcast Section Editor for Neurology and has received research support from Western Institute for Biomedical Research (WIBR). Dr. Ellen Mowry has served on a liothyronine study Data and Safety Monitoring Board; serves on the editorial board of Frontiers in Neuroepidemiomology; has received royalties as an UptoDate chapter editor; has received commercial research support from Teva Neuroscience, Biogen Idec, Genzyme, and Sun Pharma; has received governmental research support from the Department of Defense; and has received foundation/society research support from the Na

1. Patient-reported outcomes across cerebrovascular event types - more similar than different 2. [What’s Trending]: Genetic landscape of pediatric movement disorders and management implications.In the first segment, Dr. Andrew Southerland talks with Dr. Irene Katzan about her paper on patient-reported outcomes across cerebrovascular event types. In the second part of the podcast, Dr. Jeff Waugh focuses his interview with Dr. Saadet Andrews on the genetic landscape of pediatric movement disorders and management implications. DISCLOSURES: Dr. Southerland has severed on editorial boards for the Journal Neurology and is Section Editor for the Neurology Podcast. Dr. Katzan served on editorial boards for Stroke (American Stroke Association) and Circulation: Cardiovascular Quality & Outcomes (American Heart Association). Dr. Katzan has received funding for research support from Novartis Pharmaceuticals and research support from the Ohio Department of Health - Physician Lead for the Ohio Paul Coverdell Stroke Reg

1. Early predictors of mortality in parkinsonism and Parkinson’s disease: a population-based study 2. [What’s Trending]: Data from the Largest Natural History Study of Stiff Person Syndrome. In the first segment, Dr. Jeffery Ratliff talks with Dr. David Bäckström about his paper on Early predictors of mortality in parkinsonism and Parkinson’s disease. In the second part of the podcast, Dr. Jeffery Ratliff focuses his interview with Marinos Dalakas on Stiff Person Syndrome. DISCLOSURES:Dr. Jeff Ratliff has received speaker honoraria from Teva and US WorldMeds LLC; is the deputy editor for the Neurology Podcast; has been a consultant for UCB Pharmaceuticals, US WorldMeds LLC, Medscape, and Retrophin Inc; and has served on speakers' bureaus for Teva and US WorldMeds LLC. Dr. David C Bäckström holds patents for chemical compounds that may be developed as treatments for premenstrual dysphoric disorder, but has not received any personal compensation for the patents. Dr. David C Bäckström has received Research Suppo

1. Devastating neurological injuries in the Syrian War 2. [What’s Trending]: Standards for Neurologic Critical Care Units: A Statement for Healthcare Professionals from The Neurocritical Care Society. In the first segment, Dr. Jason Crowell talks with Dr. Maher Saqqur and Yasmeen El Hajj Abdallah about neurological injuries in the Syrian War. In the second part of the podcast, Dr. Andrew Schomer focuses his interview with Dr. Asma Moheet on Standards for Neurologic Critical Care Units. DISCLOSURES: Drs. Jason Crowell, Maher Saqqur, Asma Moheet, and Andrew Schomer report no disclosures. Yasmeen El Hajj Abdallah reports employment with Shoppers Drugmart Pharmacy as pharmacy student for less than one year.

Dr. Alex Menze focuses his interview with Claudia Angeli on recovery of over-ground walking after chronic motor complete spinal cord injury. 

1. Featured Article Use of newer disease-modifying therapies in pediatric multiple sclerosis in the US 2. [What’s Trending]: Acute flaccid myelitis In the first segment, Dr. Nick Brenton talks with Dr. Kristen Krysko about her paper on therapies for pediatric multiple sclerosis. In the second part of the podcast, Dr. Stacey Clardy focuses her interview with Dr. Kenneth Tyler on acute flaccid myelitis. DISCLOSURES: Dr. Nick Brenton does not report any disclosures.Dr. Kristen Krysko received fellowship support from he National Multiple Sclerosis Society.Dr. Clardy has received research support from Western Institute for Biomedical Research (WIBR). Dr. Tyler serves as an Associate Editor for Journal of Neurovirology and Neurology Today; serves as an editorial board member for Annals of Neurology, Apoptosis, JAMA Neurology, Experimental Neurology, Journal of Infectious Disease, Microbial Pathogenesis, Virology, Neurology ALL Current; serves on the scientific advisory board for DNAtrix (DSMB, active), LPath (DSMB)

This month’s Delayed Recall highlights episodes on stroke risk, prevention and treatment. Dr. Jim Siegler and Dr. Christian Gerloff begin the show discussing the results of the WAKE-UP stroke trial. This episode first aired on October 2, 2018. The next segment, from September 11, 2018 focuses on acute ischemic stroke, where Dr. Dan Ackerman talks with Dr. Andrei Alexandrov about his paper on dual antiplatelet therapy pretreatment. This interview is followed by a segment that first appeared in the August 21, 2018 show on silent infarct and the risk of infarct recurrence in adults with sickle cell anemia with Dr. Justin Sattin and Dr. Lori Jordan. The episode concludes with another interview on acute ischemic stroke from August 14, 2018 investigating a POINT study on Clopidogrel and aspirin in acute ischemic stroke and high-risk TIA with Dr. Will Rondeau interviewing Dr. Clay Johnston.

1. Featured Article: Quality improvement in neurology: Epilepsy Quality Measurement Set 2017 Update2. What’s Trending: Using artificial intelligence in neurological diagnosisDr. Jeff Ratliff talks with Dr. Anup Patel about his paper on the 2017 epilepsy quality measurement set update. In the second part of the podcast, Dr. Andy Southerland focuses his interview with Dr. Eric Oermann on the use of artificial intelligence in diagnosing neurological conditions. DISCLOSURES: Dr. Anup D Patel has been a consultant for Greenwich Biosciences, UCB Pharma, LivaNova, and Supernus. Dr. Patel’s other activities include Greenwich Biosciences, UCB Pharma, LivaNova, and Supernus. Dr. Patel’s has received research support for commercial entities from Greenwich Biosciences Brain Sentinel Upsher Smith Pharmaceuticals LivaNova, and research support from foundations and societies from Pediatric Epilepsy Research Foundation (PERF) American Academy of Neurology (AAN). Dr. Patel’s non-financial disclosures include serving on a volu